Cooperative effect of oncogenic MET and PIK3CA in an HGF-dominant environment in breast cancer

There is compelling evidence that oncogenic MET and PIK3CA signaling pathways contribute to breast cancer. However, the activity of pharmacological targeting of either pathway is modest. Mechanisms of resistance to these monotherapies have not been clarified. Currently commonly used mouse models are...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Liu, Shuying, Li, Shunqiang, Wang, Bailiang, Liu, Wenbin, Gagea, Mihai, Chen, Huiqin, Sohn, Joohyuk, Parinyanitikul, Napa, Primeau, Tina, Do, Kim-Anh, Vande Woude, George F., Mendelsohn, John, Ueno, Naoto T., Mills, Gordon B., Tripathy, Debu, Gonzalez-Angulo, Ana M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357548/
https://ncbi.nlm.nih.gov/pubmed/30518672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0710
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