Chromosome Engineering To Generate Plasmid-Free Phenylalanine- and Tyrosine-Overproducing Escherichia coli Strains That Can Be Applied in the Generation of Aromatic-Compound-Producing Bacteria

Many phenylalanine- and tyrosine-producing strains have used plasmid-based overexpression of pathway genes. The resulting strains achieved high titers and yields of phenylalanine and tyrosine. Chromosomally engineered, plasmid-free producers have shown lower titers and yields than plasmid-based stra...

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Bibliographic Details
Published in:Appl Environ Microbiol
Main Authors: Koma, Daisuke, Kishida, Takahiro, Yoshida, Eisuke, Ohashi, Hiroyuki, Yamanaka, Hayato, Moriyoshi, Kunihiko, Nagamori, Eiji, Ohmoto, Takashi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Biotechnology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357484/
https://ncbi.nlm.nih.gov/pubmed/32414798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00525-20
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