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Pooled CRISPR screens with imaging on microRaft arrays reveals stress granule-regulatory factors
Genetic screens using pooled CRISPR-based approaches are scalable and inexpensive, but restricted to standard readouts including survival, proliferation and sortable markers. However, many biologically relevant cell states involve cellular and subcellular changes that are only accessible by microsco...
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| Publié dans: | Nat Methods |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7357298/ https://ncbi.nlm.nih.gov/pubmed/32393832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-020-0826-8 |
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