Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking

Adeno-associated viruses (AAVs) are small, non-pathogenic ssDNA viruses being used as therapeutic gene delivery vectors for the treatment of a variety of monogenic diseases. An obstacle to successful gene delivery is inefficient capsid trafficking through the endo/lysosomal pathway. This study aimed...

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Detalhes bibliográficos
Publicado no:Viruses
Main Authors: Lins-Austin, Bridget, Patel, Saajan, Mietzsch, Mario, Brooke, Dewey, Bennett, Antonette, Venkatakrishnan, Balasubramanian, Van Vliet, Kim, Smith, Adam N., Long, Joanna R., McKenna, Robert, Potter, Mark, Byrne, Barry, Boye, Sanford L., Bothner, Brian, Heilbronn, Regine, Agbandje-McKenna, Mavis
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354436/
https://ncbi.nlm.nih.gov/pubmed/32575696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v12060668
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