Integrated analysis of optical mapping and whole-genome sequencing reveals intratumoral genetic heterogeneity in metastatic lung squamous cell carcinoma

BACKGROUND: Intratumoral heterogeneity is a crucial factor to the outcome of patients and resistance to therapies, in which structural variants play an indispensable but undiscovered role. METHODS: We performed an integrated analysis of optical mapping and whole-genome sequencing on a primary tumor...

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Detalhes bibliográficos
Publicado no:Transl Lung Cancer Res
Main Authors: Peng, Yizhou, Yuan, Chongze, Tao, Xiaoting, Zhao, Yue, Yao, Xingxin, Zhuge, Lingdun, Huang, Jianwei, Zheng, Qiang, Zhang, Yue, Hong, Hui, Chen, Haiquan, Sun, Yihua
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7354123/
https://ncbi.nlm.nih.gov/pubmed/32676329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tlcr-19-401
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