Chemokine Receptor Antagonists in Combination with Morphine as a Novel Strategy for Opioid Dose Reduction in Pain Management

INTRODUCTION: Although opioids are widely prescribed for pain, in many circumstances, they have only modest efficacy. Preclinical studies have shown that chemokines, immune mediators released during tissue injury and inflammation, can desensitize opioid receptors and block opioid analgesia by a proc...

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Udgivet i:Mil Med
Main Authors: Eisenstein, Toby K, Chen, Xiaohong, Inan, Saadet, Meissler, Joseph J, Tallarida, Christopher S, Geller, Ellen B, Rawls, Scott M, Cowan, Alan, Adler, Martin W
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Supplement Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7353838/
https://ncbi.nlm.nih.gov/pubmed/32074321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/milmed/usz320
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