Chemokine Receptor Antagonists in Combination with Morphine as a Novel Strategy for Opioid Dose Reduction in Pain Management

INTRODUCTION: Although opioids are widely prescribed for pain, in many circumstances, they have only modest efficacy. Preclinical studies have shown that chemokines, immune mediators released during tissue injury and inflammation, can desensitize opioid receptors and block opioid analgesia by a proc...

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Detalhes bibliográficos
Publicado no:Mil Med
Main Authors: Eisenstein, Toby K, Chen, Xiaohong, Inan, Saadet, Meissler, Joseph J, Tallarida, Christopher S, Geller, Ellen B, Rawls, Scott M, Cowan, Alan, Adler, Martin W
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Supplement Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7353838/
https://ncbi.nlm.nih.gov/pubmed/32074321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/milmed/usz320
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