Coadministration of Chemokine Receptor Antagonists with Morphine Potentiates Morphine’s Analgesic Effect on Incisional Pain in Rats

Crossdesensitization between opioid and chemokine receptors and involvement of chemokines in pain modulation are well established. We investigated if coadministration of chemokine receptor antagonists (CRAs) with morphine would enhance the analgesic potency of morphine on incisional pain in rats. An...

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Udgivet i:J Pharmacol Exp Ther
Main Authors: Inan, Saadet, Eisenstein, Toby K., Watson, Mia N., Doura, Menahem, Meissler, Joseph J., Tallarida, Christopher S., Chen, Xiaohong, Geller, Ellen B., Rawls, Scott M., Cowan, Alan, Adler, Martin W.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2018
Fag:
Behavioral Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226546/
https://ncbi.nlm.nih.gov/pubmed/30249618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.252890
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