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Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes

Genetic association studies have shown their usefulness in assessing the role of ion channels in human thermal pain perception. We used machine learning to construct a complex phenotype from pain thresholds to thermal stimuli and associate it with the genetic information derived from the next-genera...

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Dettagli Bibliografici
Pubblicato in:Int J Mol Sci
Autori principali: Lötsch, Jörn, Kringel, Dario, Geisslinger, Gerd, Oertel, Bruno G., Resch, Eduard, Malkusch, Sebastian
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352872/
https://ncbi.nlm.nih.gov/pubmed/32575443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21124367
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