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Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes

Genetic association studies have shown their usefulness in assessing the role of ion channels in human thermal pain perception. We used machine learning to construct a complex phenotype from pain thresholds to thermal stimuli and associate it with the genetic information derived from the next-genera...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Lötsch, Jörn, Kringel, Dario, Geisslinger, Gerd, Oertel, Bruno G., Resch, Eduard, Malkusch, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352872/
https://ncbi.nlm.nih.gov/pubmed/32575443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21124367
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