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Machine-learned analysis of the association of next-generation sequencing–based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin

Heat pain and its modulation by capsaicin varies among subjects in experimental and clinical settings. A plausible cause is a genetic component, of which TRPV1 ion channels, by their response to both heat and capsaicin, are primary candidates. However, TRPA1 channels can heterodimerize with TRPV1 ch...

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發表在:Pain
Main Authors: Kringel, Dario, Geisslinger, Gerd, Resch, Eduard, Oertel, Bruno G., Thrun, Michael C., Heinemann, Sarah, Lötsch, Jörn
格式: Artigo
語言:Inglês
出版: Wolters Kluwer 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012053/
https://ncbi.nlm.nih.gov/pubmed/29596157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001222
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