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Machine-learned analysis of the association of next-generation sequencing–based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin

Heat pain and its modulation by capsaicin varies among subjects in experimental and clinical settings. A plausible cause is a genetic component, of which TRPV1 ion channels, by their response to both heat and capsaicin, are primary candidates. However, TRPA1 channels can heterodimerize with TRPV1 ch...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Kringel, Dario, Geisslinger, Gerd, Resch, Eduard, Oertel, Bruno G., Thrun, Michael C., Heinemann, Sarah, Lötsch, Jörn
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012053/
https://ncbi.nlm.nih.gov/pubmed/29596157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001222
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