SPOP Deregulation Improves the Radiation Response of Prostate Cancer Models by Impairing DNA Damage Repair

Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is the most commonly mutated gene in prostate cancer (PCa). Recent evidence reports a role of SPOP in DNA damage response (DDR), indicating a possible impact of SPOP deregulation on PCa radiosensitivity. This study aimed to define t...

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Publicat a:Cancers (Basel)
Autors principals: El Bezawy, Rihan, Tripari, Martina, Percio, Stefano, Cicchetti, Alessandro, Tortoreto, Monica, Stucchi, Claudio, Tinelli, Stella, Zuco, Valentina, Doldi, Valentina, Gandellini, Paolo, Valdagni, Riccardo, Zaffaroni, Nadia
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352729/
https://ncbi.nlm.nih.gov/pubmed/32512734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061462
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