Luminal STIM1 Mutants that Cause Tubular Aggregate Myopathy Promote Autophagic Processes

Stromal interaction molecule 1 (STIM1) is a ubiquitously expressed Ca(2+) sensor protein that induces permeation of Orai Ca(2+) channels upon endoplasmic reticulum Ca(2+)-store depletion. A drop in luminal Ca(2+) causes partial unfolding of the N-terminal STIM1 domains and thus initial STIM1 activat...

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Udgivet i:Int J Mol Sci
Main Authors: Sallinger, Matthias, Tiffner, Adéla, Schmidt, Tony, Bonhenry, Daniel, Waldherr, Linda, Frischauf, Irene, Lunz, Victoria, Derler, Isabella, Schober, Romana, Schindl, Rainer
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352373/
https://ncbi.nlm.nih.gov/pubmed/32575830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21124410
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