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Revisiting NO(2) as Protecting Group of Arginine in Solid-Phase Peptide Synthesis

The protection of side-chain arginine in solid-phase peptide synthesis requires attention since current protecting groups have several drawbacks. Herein, the NO(2) group, which is scarcely used, has been revisited. This work shows that it prevents the formation of δ-lactam, the most severe side-reac...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Alhassan, Mahama, Kumar, Ashish, Lopez, John, Albericio, Fernando, de la Torre, Beatriz G.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352207/
https://ncbi.nlm.nih.gov/pubmed/32586051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21124464
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