Revisiting NO(2) as Protecting Group of Arginine in Solid-Phase Peptide Synthesis

The protection of side-chain arginine in solid-phase peptide synthesis requires attention since current protecting groups have several drawbacks. Herein, the NO(2) group, which is scarcely used, has been revisited. This work shows that it prevents the formation of δ-lactam, the most severe side-reac...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Alhassan, Mahama, Kumar, Ashish, Lopez, John, Albericio, Fernando, de la Torre, Beatriz G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352207/
https://ncbi.nlm.nih.gov/pubmed/32586051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21124464
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