Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16

PURPOSE: Despite contemporary treatment, up to 10% of children with acute lymphoblastic leukemia still experience relapse. We evaluated whether a higher dosage of PEG-asparaginase and early intensification of triple intrathecal therapy would improve systemic and CNS control. PATIENTS AND METHODS: Be...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Jeha, Sima, Pei, Deqing, Choi, John, Cheng, Cheng, Sandlund, John T., Coustan-Smith, Elaine, Campana, Dario, Inaba, Hiroto, Rubnitz, Jeffrey E., Ribeiro, Raul C., Gruber, Tanja A., Raimondi, Susana C., Khan, Raja B., Yang, Jun J., Mullighan, Charles G., Downing, James R., Evans, William E., Relling, Mary V., Pui, Ching-Hon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
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ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351342/
https://ncbi.nlm.nih.gov/pubmed/31657981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.19.01692
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