Treatment of Childhood Acute Lymphoblastic Leukemia Without Prophylactic Cranial Irradiation

BACKGROUND: We conducted a clinical trial to test whether prophylactic cranial irradiation could be omitted in all children with newly diagnosed acute lymphoblastic leukemia. METHODS: A total of 498 evaluable patients were enrolled. Treatment intensity was based on presenting features and the level...

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Detalhes bibliográficos
Main Authors: Pui, Ching-Hon, Campana, Dario, Pei, Deqing, Bowman, W. Paul, Sandlund, John T., Kaste, Sue C., Ribeiro, Raul C., Rubnitz, Jeffrey E., Raimondi, Susana C., Onciu, Mihaela, Coustan-Smith, Elaine, Kun, Larry E., Jeha, Sima, Cheng, Cheng, Howard, Scott C., Simmons, Vickey, Bayles, Amy, Metzger, Monika L., Boyett, James M., Leung, Wing, Handgretinger, Rupert, Downing, James R., Evans, William E., Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754320/
https://ncbi.nlm.nih.gov/pubmed/19553647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa0900386
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