Synthesis, biological evaluation, and modeling studies of 1,3-disubstituted cyclobutane-containing analogs of combretastatin A4

With the aim of circumventing the adverse cis/trans-isomerization of combretastatin A4 (CA4), a naturally occurring tumor-vascular disrupting agent, we designed novel CA4 analogs bearing 1,3-cyclobutane moiety instead of the cis-stilbene unit of the parent compound. The corresponding cis and trans c...

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Publicado no:J Mol Struct
Main Authors: Malashchuk, Andrii, Chernykh, Anton V., Hurmach, Vasyl V., Platonov, Maxim O., Onopchenko, Oleksandra, Zozulya, Sergey, Daniliuc, Constantin G., Dobrydnev, Alexey V., Kondratov, Ivan S., Moroz, Yuriy S., Grygorenko, Oleksandr O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351177/
https://ncbi.nlm.nih.gov/pubmed/32655187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molstruc.2020.128025
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