Multigram Synthesis of 2-Azabicyclo[2.1.1]hexane-1-Carboxylates (2,4-Methanoprolines) – Promising Bicyclic Proline Analogs

An optimized approach towards 4-substituted 2,4-methanoproline derivatives is reported. Careful selection of the starting materials and optimized isolation procedure provided easy access to a key bicyclic building block in a preparative yield of 32% over five laboratory steps of up to 0.7 kg. Furthe...

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主要な著者:	Anton V. Chernykh, Oleksandr S. Liashuk, Anastasiia M. Hurieva, Dmytro M. Volochnyuk, Oleksandr O. Grygorenko
フォーマット:	Artigo
言語:	Inglês
出版事項:	National University of Pharmacy (Kharkiv) 2024-12-01
シリーズ:	Журнал органічної та фармацевтичної хімії
主題:	bicyclic compounds building blocks proline analog bridged pyrrolidine amino acid
オンライン･アクセス:	https://ophcj.nuph.edu.ua/article/view/314843
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