Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis

BACKGROUND: Mutations in the gene that encodes the lysosomal cystine transporter cystinosin cause the lysosomal storage disease cystinosis. Defective cystine transport leads to intralysosomal accumulation and crystallization of cystine. The most severe phenotype, nephropathic cystinosis, manifests d...

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Publicado en:J Am Soc Nephrol
Autores principales: De Leo, Ester, Elmonem, Mohamed A., Berlingerio, Sante Princiero, Berquez, Marine, Festa, Beatrice Paola, Raso, Roberto, Bellomo, Francesco, Starborg, Tobias, Janssen, Manoe Jacoba, Abbaszadeh, Zeinab, Cairoli, Sara, Goffredo, Bianca Maria, Masereeuw, Rosalinde, Devuyst, Olivier, Lowe, Martin, Levtchenko, Elena, Luciani, Alessandro, Emma, Francesco, Rega, Laura Rita
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2020
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351012/
https://ncbi.nlm.nih.gov/pubmed/32503896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019090956
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