Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis

BACKGROUND: Mutations in the gene that encodes the lysosomal cystine transporter cystinosin cause the lysosomal storage disease cystinosis. Defective cystine transport leads to intralysosomal accumulation and crystallization of cystine. The most severe phenotype, nephropathic cystinosis, manifests d...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: De Leo, Ester, Elmonem, Mohamed A., Berlingerio, Sante Princiero, Berquez, Marine, Festa, Beatrice Paola, Raso, Roberto, Bellomo, Francesco, Starborg, Tobias, Janssen, Manoe Jacoba, Abbaszadeh, Zeinab, Cairoli, Sara, Goffredo, Bianca Maria, Masereeuw, Rosalinde, Devuyst, Olivier, Lowe, Martin, Levtchenko, Elena, Luciani, Alessandro, Emma, Francesco, Rega, Laura Rita
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2020
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351012/
https://ncbi.nlm.nih.gov/pubmed/32503896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019090956
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