Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis

BACKGROUND: Mutations in the gene that encodes the lysosomal cystine transporter cystinosin cause the lysosomal storage disease cystinosis. Defective cystine transport leads to intralysosomal accumulation and crystallization of cystine. The most severe phenotype, nephropathic cystinosis, manifests d...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: De Leo, Ester, Elmonem, Mohamed A., Berlingerio, Sante Princiero, Berquez, Marine, Festa, Beatrice Paola, Raso, Roberto, Bellomo, Francesco, Starborg, Tobias, Janssen, Manoe Jacoba, Abbaszadeh, Zeinab, Cairoli, Sara, Goffredo, Bianca Maria, Masereeuw, Rosalinde, Devuyst, Olivier, Lowe, Martin, Levtchenko, Elena, Luciani, Alessandro, Emma, Francesco, Rega, Laura Rita
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2020
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7351012/
https://ncbi.nlm.nih.gov/pubmed/32503896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019090956
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