Methadone Inhibits Viral Restriction Factors and Facilitates HIV Infection in Macrophages

Opioid abuse alters the functions of immune cells in both in vitro and in vivo systems, including macrophages. Here, we investigated the effects of methadone, a widely used opioid receptor agonist for treatment of opiate addiction, on the expression of intracellular viral restriction factors and HIV...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Wang, Mei-Rong, Wu, Di-Di, Luo, Fan, Zhong, Chao-Jie, Wang, Xin, Zhu, Ni, Wu, Ying-Jun, Hu, Hai-Tao, Feng, Yong, Wang, Xu, Xiong, Hai-Rong, Hou, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350609/
https://ncbi.nlm.nih.gov/pubmed/32719674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01253
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