RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

How somatic mutations accumulate in normal cells is poorly understood. A comprehensive analysis of RNA-sequencing data from ~6,700 samples across 29 normal tissues reveals multiple somatic variants, demonstrating that macroscopic clones can be found in many normal tissues. We confirm that sun-expose...

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Pubblicato in:Science
Autori principali: Yizhak, Keren, Aguet, Francois, Kim, Jaegil, Hess, Julian, Kübler, Kirsten, Grimsby, Jonna, Frazer, Ruslana, Zhang, Hailei, Haradhvala, Nicholas J., Rosebrock, Daniel, Livitz, Dimitri, Li, Xiao, Arich- Landkof, Eila, Shoresh, Noam, Stewart, Chip, Segrè, Ayelet V., Branton, Philip A., Polak, Paz, Ardlie, Kristin, Getz, Gad
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350423/
https://ncbi.nlm.nih.gov/pubmed/31171663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw0726
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