Pathogenic Prion Protein Isoforms Are Not Present in Cerebral Organoids Generated from Asymptomatic Donors Carrying the E200K Mutation Associated with Familial Prion Disease

Cerebral organoids (COs) are a self-organizing three-dimensional brain tissue mimicking the human cerebral cortex. COs are a promising new system for modelling pathological features of neurological disorders, including prion diseases. COs expressing normal prion protein (PrPC) are susceptible to pri...

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Veröffentlicht in:Pathogens
Hauptverfasser: Foliaki, Simote T., Groveman, Bradley R., Yuan, Jue, Walters, Ryan, Zhang, Shulin, Tesar, Paul, Zou, Wenquan, Haigh, Cathryn L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7350378/
https://ncbi.nlm.nih.gov/pubmed/32570796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens9060482
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