Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs

[Image: see text] Proteolysis targeting chimeras (PROTACs) represent an exciting inhibitory modality with many advantages, including substoichiometric degradation of targets. Their scope, though, is still limited to date by the requirement for a sufficiently potent target binder. A solution that pro...

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Pubblicato in:J Am Chem Soc
Autori principali: Gabizon, Ronen, Shraga, Amit, Gehrtz, Paul, Livnah, Ella, Shorer, Yamit, Gurwicz, Neta, Avram, Liat, Unger, Tamar, Aharoni, Hila, Albeck, Shira, Brandis, Alexander, Shulman, Ziv, Katz, Ben-Zion, Herishanu, Yair, London, Nir
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7349657/
https://ncbi.nlm.nih.gov/pubmed/32369353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b13907
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