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Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs
[Image: see text] Proteolysis targeting chimeras (PROTACs) represent an exciting inhibitory modality with many advantages, including substoichiometric degradation of targets. Their scope, though, is still limited to date by the requirement for a sufficiently potent target binder. A solution that pro...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2020
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7349657/ https://ncbi.nlm.nih.gov/pubmed/32369353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b13907 |
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