Desialylation of Sonic-Hedgehog by Neu2 Inhibits Its Association with Patched1 Reducing Stemness-Like Properties in Pancreatic Cancer Sphere-forming Cells

Cancer stem cells (CSCs) are crucial regulators of tumor recurrence/progression. The maintenance of CSCs is dependent on aberrant activation of various pathways, including Hedgehog. Prevalent sialylations contribute to aggressiveness in CSCs. Here, we have addressed the role of sialylation in regula...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cells
मुख्य लेखकों: Nath, Shalini, Mondal, Susmita, Butti, Ramesh, Prasanna Gunasekaran, Vinoth, Chatterjee, Uttara, Halder, Aniket, Kundu, Gopal C., Mandal, Chitra
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: MDPI 2020
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7349614/
https://ncbi.nlm.nih.gov/pubmed/32575925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9061512
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