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Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells

Modulation of sialylation by sialyltransferases and sialidases plays essential role in carcinogenesis. There are few reports on sialyltransferase, however, the contribution of cytosolic sialidase (Neu2) remains unexplored in pancreatic ductal adenocarcinoma (PDAC). We observed lower expression of Ne...

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Библиографические подробности
Опубликовано в: :Cell Death Dis
Главные авторы: Nath, Shalini, Mandal, Chhabinath, Chatterjee, Uttara, Mandal, Chitra
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833727/
https://ncbi.nlm.nih.gov/pubmed/29434218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0191-4
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