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Overlap of Peak Growth Activity and Peak IGF-1 to IGFBP Ratio: Delayed Increase of IGFBPs Versus IGF-1 in Serum as a Mechanism to Speed up and down Postnatal Weight Gain in Mice

Forced expression of insulin-like growth factor binding proteins (IGFBPs) in transgenic mice has clearly revealed inhibitory effects on somatic growth. However, by this approach, it cannot be solved if or how IGFBPs rule insulin-like growth factor (IGF)-dependent growth under normal conditions. In o...

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Bibliografiske detaljer
Udgivet i:Cells
Main Authors: Walz, Michael, Chau, Luong, Walz, Christina, Sawitzky, Mandy, Ohde, Daniela, Brenmoehl, Julia, Tuchscherer, Armin, Langhammer, Martina, Metzger, Friedrich, Höflich, Christine, Hoeflich, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7348928/
https://ncbi.nlm.nih.gov/pubmed/32580353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9061516
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