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Transcriptomic analysis of pulmonary artery smooth muscle cells identifies new potential therapeutic targets for idiopathic pulmonary arterial hypertension

BACKGROUND AND PURPOSE: Pulmonary arterial hypertension (PAH, type 1 pulmonary hypertension) has a 3‐year survival of ~50% and is in need of new, effective therapies. In PAH, remodelling of the pulmonary artery (PA) increases pulmonary vascular resistance and can result in right heart dysfunction an...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Gorr, Matthew W., Sriram, Krishna, Muthusamy, Abinaya, Insel, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7348089/
https://ncbi.nlm.nih.gov/pubmed/32337710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15074
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