Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing

Outcome of immune checkpoint inhibition in cancer can be predicted by measuring PDL1 expression of tumor cells. Search for additional biomarkers led to tumor mutational burden (TMB) as surrogate marker for neoantigens presented. While TMB was previously determined via whole exome sequencing (WES), t...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Heydt, Carina, Rehker, Jan, Pappesch, Roberto, Buhl, Theresa, Ball, Markus, Siebolts, Udo, Haak, Anja, Lohneis, Philipp, Büttner, Reinhard, Hillmer, Axel M., Merkelbach-Bruse, Sabine
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347536/
https://ncbi.nlm.nih.gov/pubmed/32647293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68394-4
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