Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing

Outcome of immune checkpoint inhibition in cancer can be predicted by measuring PDL1 expression of tumor cells. Search for additional biomarkers led to tumor mutational burden (TMB) as surrogate marker for neoantigens presented. While TMB was previously determined via whole exome sequencing (WES), t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Heydt, Carina, Rehker, Jan, Pappesch, Roberto, Buhl, Theresa, Ball, Markus, Siebolts, Udo, Haak, Anja, Lohneis, Philipp, Büttner, Reinhard, Hillmer, Axel M., Merkelbach-Bruse, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347536/
https://ncbi.nlm.nih.gov/pubmed/32647293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68394-4
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