Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbred Drosophila melanogaster lines to a DR or ad lib...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Jin, Kelly, Wilson, Kenneth A., Beck, Jennifer N., Nelson, Christopher S., Brownridge, George W., Harrison, Benjamin R., Djukovic, Danijel, Raftery, Daniel, Brem, Rachel B., Yu, Shiqing, Drton, Mathias, Shojaie, Ali, Kapahi, Pankaj, Promislow, Daniel
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347105/
https://ncbi.nlm.nih.gov/pubmed/32644988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008835
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