Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbred Drosophila melanogaster lines to a DR or ad lib...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Jin, Kelly, Wilson, Kenneth A., Beck, Jennifer N., Nelson, Christopher S., Brownridge, George W., Harrison, Benjamin R., Djukovic, Danijel, Raftery, Daniel, Brem, Rachel B., Yu, Shiqing, Drton, Mathias, Shojaie, Ali, Kapahi, Pankaj, Promislow, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347105/
https://ncbi.nlm.nih.gov/pubmed/32644988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008835
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