Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found that genotypes within the same species vary widely in how they respond to DR. To explore the mechanisms underlying this variation, we exposed 178 inbred Drosophila melanogaster lines to a DR or ad lib...

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Publicat a:PLoS Genet
Autors principals: Jin, Kelly, Wilson, Kenneth A., Beck, Jennifer N., Nelson, Christopher S., Brownridge, George W., Harrison, Benjamin R., Djukovic, Danijel, Raftery, Daniel, Brem, Rachel B., Yu, Shiqing, Drton, Mathias, Shojaie, Ali, Kapahi, Pankaj, Promislow, Daniel
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347105/
https://ncbi.nlm.nih.gov/pubmed/32644988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008835
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