Quantification of IDO1 enzyme activity in normal and malignant tissues

Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first and rate-limiting reaction of l-tryptophan (Trp) conversion into l-kynurenine (Kyn). The depletion of Trp, and the accumulation of Kyn have been proposed as mechanisms that contribute to the suppression of the immune response—primarily evidenc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Methods Enzymol
Prif Awduron: Zhai, Lijie, Ladomersky, Erik, Bell, April, Dussold, Corey, Cardoza, Krislyn, Qian, Jun, Lauing, Kristen L., Wainwright, Derek A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347075/
https://ncbi.nlm.nih.gov/pubmed/31727243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2019.07.006
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