Structural basis for allosteric PARP-1 retention on DNA breaks

INTRODUCTION: Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant enzyme in the cell nucleus that regulates genome repair by binding to DNA damage sites and creating the poly(ADP-ribose) posttranslational modification. PARP-1 hyperactivity leads to cell stress/death associated with many prominent...

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Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Zandarashvili, Levani, Langelier, Marie-France, Velagapudi, Uday Kiran, Hancock, Mark A., Steffen, Jamin D., Billur, Ramya, Hannan, Zain M., Wicks, Andrew J., Krastev, Dragomir B., Pettitt, Stephen J., Lord, Christopher J., Talele, Tanaji T., Pascal, John M., Black, Ben E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347020/
https://ncbi.nlm.nih.gov/pubmed/32241924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax6367
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