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Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors
Poly(ADP-ribose)polymerase 1 (PARP1), a widely explored anticancer drug target, plays an important role in single-strand DNA break repair processes. High-throughput virtual screening (HTVS) of the Maybridge small molecule library using the PARP1-benzimidazole-4-carboxamide crystal structure and phar...
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| Udgivet i: | Bioorg Chem |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8142146/ https://ncbi.nlm.nih.gov/pubmed/32777641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2020.104075 |
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