Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets

CTP:phosphocholine cytidylyltransferase-alpha (CCTα) and CCTβ catalyze the rate-limiting step in phosphatidylcholine (PC) biosynthesis. CCTα is activated by association of its α-helical M-domain with nuclear membranes, which is negatively regulated by phosphorylation of the adjacent P-domain. To und...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Yue, Lambert, McPhee, Michael J., Gonzalez, Kevin, Charman, Mark, Lee, Jonghwa, Thompson, Jordan, Winkler, Dirk F. H., Cornell, Rosemary B., Pelech, Steven, Ridgway, Neale D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346725/
https://ncbi.nlm.nih.gov/pubmed/32186954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-01-0014
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