Design and Development of Novel Urea, Sulfonyltriurea, and Sulfonamide Derivatives as Potential Inhibitors of Sphingosine Kinase 1

Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics; however, selectivity and potency of first-generation inhibitors are great challenge. In sear...

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Detaylı Bibliyografya
Yayımlandı:Pharmaceuticals (Basel)
Asıl Yazarlar: Roy, Sonam, Mahapatra, Amarjyoti Das, Mohammad, Taj, Gupta, Preeti, Alajmi, Mohamed F., Hussain, Afzal, Rehman, Md. Tabish, Datta, Bhaskar, Hassan, Md. Imtaiyaz
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346089/
https://ncbi.nlm.nih.gov/pubmed/32526899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph13060118
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