Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease

The pro-inflammatory cytokine interleukin-1 (IL-1) plays a key role in many physiological processes and during the inflammatory and immune response to most common diseases. IL-1 exists as two agonists, IL-1α and IL-1β that bind to the only signaling IL-1 type 1 receptor (IL-1R1), while a second deco...

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Veröffentlicht in:J Mol Med (Berl)
Hauptverfasser: Pinteaux, Emmanuel, Abdulaal, Wesam H, Mufazalov, Ilgiz A, Humphreys, Neil E, Simonsen-Jackson, Maj, Francis, Sheila, Müller, Werner, Waisman, Ari
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2020
Schlagworte:
Review
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343756/
https://ncbi.nlm.nih.gov/pubmed/32468079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-020-01928-5
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