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Histone chaperone FACT is essential to overcome replication stress in mammalian cells
The histone chaperone FACT is upregulated during mammary tumorigenesis and necessary for the viability and growth of breast tumor cells. We established that only proliferating tumor cells are sensitive to FACT knockdown, suggesting that FACT functions during DNA replication in tumor cells but not in...
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| 發表在: | Oncogene |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7343669/ https://ncbi.nlm.nih.gov/pubmed/32533099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1346-9 |
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