Clonality and antigen-specific responses shape the prognostic effects of tumor-infiltrating T cells in ovarian cancer

CD8(+) tumor-infiltrating lymphocytes (TILs) are not all specific for tumor antigens, but can include bystander TILs that are specific for cancer-irrelevant epitopes, and it is unknown whether the T-cell repertoire affects prognosis. To delineate the complexity of anti-tumor T-cell responses, we uti...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Tsuji, Takemasa, Eng, Kevin H., Matsuzaki, Junko, Battaglia, Sebastiano, Szender, J. Brian, Miliotto, Anthony, Gnjatic, Sacha, Bshara, Wiam, Morrison, Carl D., Lele, Shashikant, Emerson, Ryan O., Wang, Jianmin, Liu, Song, Robins, Harlan, Lugade, Amit A., Odunsi, Kunle
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343634/
https://ncbi.nlm.nih.gov/pubmed/32676168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27666
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