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Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations
Drug resistance is a serious problem for treatment of the HIV/AIDS pandemic. Potent clinical inhibitors of HIV-1 protease show several orders of magnitude worse inhibition of highly drug resistant variants. Hence, the structure and enzyme activity were analyzed for HIV protease mutant PRS5B from a c...
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| Publicado no: | FEBS J |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7343616/ https://ncbi.nlm.nih.gov/pubmed/31920003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15207 |
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