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Conformational Variation of an Extreme Drug Resistant Mutant of HIV Protease
Molecular mechanisms leading to high level drug resistance have been analyzed for the clinical variant of HIV-1 protease bearing 20 mutations (PR20); which has several orders of magnitude worse affinity for tested drugs. Two crystal structures of ligand-free PR20 with the D25N mutation of the cataly...
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| Publicado no: | J Mol Graph Model |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4695280/ https://ncbi.nlm.nih.gov/pubmed/26397743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2015.09.006 |
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