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Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics
Mendelian randomization (MR) is a valuable tool for detecting causal effects using genetic variant associations. Opportunities to apply MR are growing rapidly with the number of genome-wide association studies (GWAS). However, existing MR methods rely on strong assumptions that are often violated, l...
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| Publicado no: | Nat Genet |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7343608/ https://ncbi.nlm.nih.gov/pubmed/32451458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0631-4 |
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