Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

Yeast DEAD-box helicase Ded1 stimulates translation initiation, particularly of mRNAs with structured 5'UTRs. Interactions of the Ded1 N-terminal domain (NTD) with eIF4A, and Ded1-CTD with eIF4G, subunits of eIF4F, enhance Ded1 unwinding activity and stimulation of preinitiation complex (PIC) a...

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Publicado en:eLife
Autores principales: Gulay, Suna, Gupta, Neha, Lorsch, Jon R, Hinnebusch, Alan G
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343385/
https://ncbi.nlm.nih.gov/pubmed/32469309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58243
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