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Dysmyelinated axons in shiverer mice are highly vulnerable to α-Amino-3-hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA) receptor-mediated toxicity.
Glutamate excitotoxicity plays a role in white matter injury in many neurological diseases. Oligodendrocytes in particular are highly vulnerable to excitotoxicity, mediated through activation of AMPA/Kainate receptors. Myelin may also be injured independently via NMDA (N-methyl-D-aspartic acid) rece...
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| 出版年: | Brain Res |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7343376/ https://ncbi.nlm.nih.gov/pubmed/19896473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2009.10.066 |
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