Dysmyelinated axons in shiverer mice are highly vulnerable to α-Amino-3-hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA) receptor-mediated toxicity.

Glutamate excitotoxicity plays a role in white matter injury in many neurological diseases. Oligodendrocytes in particular are highly vulnerable to excitotoxicity, mediated through activation of AMPA/Kainate receptors. Myelin may also be injured independently via NMDA (N-methyl-D-aspartic acid) rece...

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Vydáno v:Brain Res
Hlavní autoři: Pitt, David, Gonzales, Ernesto, Cross, Anne H., Goldberg, Mark P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7343376/
https://ncbi.nlm.nih.gov/pubmed/19896473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2009.10.066
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