Humanized GPRC6A(KGKY) is a gain-of-function polymorphism in mice

GPRC6A is proposed to regulate energy metabolism in mice, but in humans a KGKY polymorphism in the third intracellular loop (ICL3) is proposed to result in intracellular retention and loss-of-function. To test physiological importance of this human polymorphism in vivo, we performed targeted genomic...

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Vydáno v:Sci Rep
Hlavní autoři: Pi, Min, Xu, Fuyi, Ye, Ruisong, Nishimoto, Satoru K., Kesterson, Robert A., Williams, Robert W., Lu, Lu, Quarles, L. Darryl
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341878/
https://ncbi.nlm.nih.gov/pubmed/32636482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68113-z
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