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Humanized GPRC6A(KGKY) is a gain-of-function polymorphism in mice
GPRC6A is proposed to regulate energy metabolism in mice, but in humans a KGKY polymorphism in the third intracellular loop (ICL3) is proposed to result in intracellular retention and loss-of-function. To test physiological importance of this human polymorphism in vivo, we performed targeted genomic...
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| Izdano u: | Sci Rep |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7341878/ https://ncbi.nlm.nih.gov/pubmed/32636482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68113-z |
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