CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model

BACKGROUND: GPRC6A is implicated in the pathogenesis of prostate cancer, but its role remains uncertain because of a purported tolerant gene variant created by substitution of a K..Y polymorphism in the 3rd intracellular loop (IL) that evolved in the majority of humans and replaces the ancestral RKL...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Ye, Ruisong, Pi, Min, Cox, John V., Nishimoto, Satoru K., Quarles, L. Darryl
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490090/
https://ncbi.nlm.nih.gov/pubmed/28659174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0561-x
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