Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil

Omecamtiv mecarbil (OM) is a putative positive inotropic tool for treatment of systolic heart dysfunction, based on the finding that in vivo it increases the ejection fraction and in vitro it prolongs the actin-bond life time of the cardiac and slow-skeletal muscle isoforms of myosin. OM action in s...

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Published in:Nat Commun
Main Authors: Governali, Serena, Caremani, Marco, Gallart, Cristina, Pertici, Irene, Stienen, Ger, Piazzesi, Gabriella, Ottenheijm, Coen, Lombardi, Vincenzo, Linari, Marco
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341760/
https://ncbi.nlm.nih.gov/pubmed/32636378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17143-2
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