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Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT(7A)R ligands
Aporphine alkaloids containing a C10 nitrogen motif were synthesized and evaluated for affinity at 5-HT(1A)R, 5-HT(2A)R, 5-HT(6)R and 5-HT(7A)R. Three series of racemic aporphines were investigated: 1,2,10-trisubstituted, C10 N-monosubstituted and compounds containing a C10 benzofused aminothiazole...
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| Gepubliceerd in: | Bioorg Med Chem |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7340851/ https://ncbi.nlm.nih.gov/pubmed/32631561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115578 |
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