Mass balance and metabolite profiling of (14)C-guadecitabine in patients with advanced cancer

Purpose The objective of this mass balance trial was to determine the excretory pathways and metabolic profile of the novel anticancer agent guadecitabine in humans after administration of a (14)C-radiolabeled dose of guadecitabine. Experimental design Included patients received at least one cycle o...

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Dades bibliogràfiques
Publicat a:Invest New Drugs
Autors principals: Roosendaal, Jeroen, Rosing, Hilde, Lucas, Luc, Gebretensae, Abadi, Huitema, Alwin D. R., van Dongen, Marloes G., Beijnen, Jos H., Oganesian, Aram
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2019
Matèries:
Phase I Studies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340650/
https://ncbi.nlm.nih.gov/pubmed/31605293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-019-00854-9
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